ISO 16424:2012 is applicable to the evaluation of the homogeneity of Gd distribution within gadolinium fuel blends, and the determination of the Gd₂O₃ content in sintered fuel pellets of Gd₂O₃+UO₂ from 1 % to 10 %, by measurements of gadolinium (Gd) and uranium (U) elements using ICP-AES.

After performing measurements of Gd and U elements using ICP-AES, if statistical methodology is additionally applied, homogeneity of Gd distribution within a Gd fuel pellet lot can also be evaluated. However, ISO 16424:2012 covers the statistical methodology only on a limited basis.